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KMID : 0379119820100030111
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Korean Journal of Mycology
1982 Volume.10 No. 3 p.111 ~ p.117
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Antitumor Components of Cryptoporus volvatus
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Abstract
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The carpophores of Cryptoporus vclvatus collected in Gyeong-gi Province of Korea were extracted with water and a protein-polysaccharide fraction was obtained after dialysis and mophilization. The antitumor activity of this fraction was tested against surcoma 180 implanted m A-strain mice. The tumor inhibition ratio was 80.4% in case ut the high dose group (50㎎/㎏, ip, 10 days) and 70.3% in the low dose group (20㎎/㎏, ip, 10 days). The protein-polysaccharide fraction was chemically analyzed and was found to be a complex of a protein which was 18.2% of the fraction when determined by Lowry-Folin method, and a polysaccharide which was 55.3% of they fraction when determined by Anthrone method. Their subunits were identified as four monosaccharides and 18 amino acids by gas-liquid chromatography and amino acid autoanalysis.
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